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Ulcerative Colitis

What is ulcerative colitis?

Ulcerative colitis is part of a group of diseases called inflammatory bowel disease (IBD).

It is when the lining of your large intestine (the colon or large bowel) and your rectum become red and swollen or inflamed. In most cases the inflammation begins in your rectum and lower intestine and moves up to the whole colon.

Ulcerative colitis does not normally affect the small intestine. But it can affect the lower section of your small intestine (the ileum).

The inflammation causes diarrhea, making your colon empty itself often. As the cells on the lining of the colon die and come off, open sores or ulcers form. These ulcers may cause pus, mucus, and bleeding.

In most cases ulcerative colitis starts when you are between the ages of 15 and 30 years old. Sometimes children and older people get it. It affects both men and women and seems to run in some families (is hereditary).

Ulcerative colitis is a long-term, chronic disease. There may be times when your symptoms go away and you are in remission for months or even years. But the symptoms will come back.

If only your rectum and lower colon are affected, your risk of colon cancer is not higher than normal. Your risk is higher than normal if the disease affects your whole colon.

In rare cases, when severe problems occur, ulcerative colitis can lead to death.

What causes ulcerative colitis?

Experts don’t know what causes ulcerative colitis.

It may be that a virus or a bacteria affects the body's infection-fighting system (immune system). The immune system may create abnormal redness and swelling (inflammation) in the intestinal wall that does not go away.

Many people with ulcerative colitis have abnormal immune systems. But experts don’t know if immune problems cause the disease. They also don’t know if ulcerative colitis may cause immune problems.

Having stress or being sensitive to some foods does not seem to cause ulcerative colitis.

Right now there is no cure, except for surgery to remove the colon.

Who is at risk for ulcerative colitis?

Some things may make you at higher risk for ulcerative colitis. These include your:

  • Age. The disease most often starts when you are between the ages of 15 and 30 years old.
  • Family history. Having a family member or close blood relative with ulcerative colitis raises your risk of getting the disease.
  • Race and ethnicity. It occurs more often in whites and people of Jewish background

What are the symptoms of ulcerative colitis?

Each person’s symptoms may vary. The most common symptoms include:

  • Belly or abdominal pain
  • Bloody diarrhea
  • Extreme tiredness (fatigue)
  • Weight loss
  • Loss of appetite
  • Rectal bleeding
  • Loss of body fluids and nutrients
  • Lack of blood (anemia) caused by severe bleeding

In some cases symptoms may also include:

  • Skin sores
  • Joint pain
  • Redness and swelling (inflammation) of the eyes
  • Liver disorders
  • Weak and brittle bones (osteoporosis)
  • Rashes
  • Kidney stones

The symptoms of ulcerative colitis may look like other health problems. Always see your health care provider to be sure.

How is ulcerative colitis diagnosed?

Your health care provider will give you a physical exam and do some blood tests. The blood tests will check if you don’t have enough healthy red blood cells (anemia). They will also check if your white blood cell count is high. This is a sign of redness and swelling (inflammation).

Other tests for ulcerative colitis include:

  • Stool culture. Checks for any abnormal bacteria in your digestive tract that may cause diarrhea and other problems. To do this, a small stool sample is taken and sent to a lab. In 2 or 3 days, the test will show if abnormal bacteria, bleeding, or infection are ­present.
  • Upper endoscopy, also called EGD (esophagogastroduodenoscopy). This test looks at the inside or lining of your food pipe (esophagus), stomach, and the top part of your small intestine (duodenum). This test uses a thin, lighted tube, called an endoscope. The tube has a camera at one end. The tube is put into your mouth and throat. Then it goes into your esophagus, stomach, and duodenum. Your health care provider can see the inside of these organs. He or she can also take a small tissue sample (biopsy) if needed.
  • Colonoscopy. This test looks at the full length of your large intestine. It can help check for any abnormal growths, tissue that is red or swollen, sores (ulcers), or bleeding. A long, flexible, lighted tube called a colonoscope is put into your rectum up into the colon. This tube lets your health care provider see your colon lining and take out a tissue sample (biopsy) to test it. He or she may also be able to treat some problems that may be found.
  • Biopsy. Your health care provider will take out a tissue sample or cells from the lining of your colon. This will be checked under a microscope.
  • Lower GI (gastrointestinal) series, also called barium enema. This is an X-ray exam of your rectum, the large intestine, and the lower part of your small intestine (the ileum). You will be given a metallic fluid called barium. Barium coats the organs so they can be seen on an X-ray. The barium is put into a tube and inserted into your rectum as an enema. An X-ray of your belly will show if you have any narrowed areas (strictures), blockages, or other problems.

How is ulcerative colitis treated?

Your health care provider will create a care plan for you based on:

  • Your age, overall health, and past health
  • How serious your case is
  • How well you handle certain medicines, treatments, or therapies
  • If your condition is expected to get worse
  • What you would like to do

There is no special diet for ulcerative colitis. But you may be able to manage mild symptoms by not eating foods that seem to upset your intestines.

Medical treatment may include:

  • Medicines. Medicines that reduce redness and swelling (inflammation) in your colon may help to ease your belly or abdominal cramps. More serious cases may need steroids, medicines that fight bacteria (antibiotics), or medicines that affect your infection-fighting system (immune system).
  • Hospitalization. This may be needed if you have severe symptoms. The goal will be to give you the nutrients you need, stop diarrhea, and replace lost blood, fluids, and electrolytes (minerals).You may need a special diet, IV (intravenous) feedings, medicines, or sometimes surgery.
  • Surgery. Most people don’t need surgery. But some people do need surgery to remove their colon. That might happen if you have heavy bleeding, are very weak after being ill for a long time, have a hole (perforation) in your colon, or are at risk for cancer. You may also need surgery if medical treatment fails or if the side effects of steroids and other medicines become harmful.

There are several types of surgery, including the following:

  • Proctocolectomy with ileostomy. This is the most common surgery. It is done when other medical treatment does not help. Your entire colon and your rectum are removed. A small opening (stoma) is made in your belly or abdominal wall. The bottom part of your small intestine (the ileum) is attached to the new opening. Your stool will come out of this opening. It will collect in a drainage bag that will be attached to you.
  • Ileoanal anastomosis. Your whole colon and the diseased lining of your rectum are removed. The outer muscles of your rectum stay in place. The bottom part of your small intestine (the ileum) is attached to the opening of your anus. A pouch is made out of the ileum. The pouch holds stool. This lets you pass stool through your anus in the normal way. You will still have fairly normal bowel movements. But your bowel movements may happen more often. They may also be more watery than normal.

What are the complications of ulcerative colitis?

Ulcerative colitis is a long-term, chronic condition. It can lead to problems over time, including:

  • Loss of appetite, leading to weight loss
  • Lack of energy (fatigue)
  • Severe bleeding (hemorrhage)
  • Hole or tear (perforation) in the colon
  • Infection of the colon
  • Severe fluid loss (dehydration)
  • Joint pain
  • Eye problems
  • Kidney stones
  • Weak, brittle bones (osteoporosis)
  • Colon cancer, if ulcerative colitis affects the whole colon over a long period of time

In rare cases, when severe problems occur, ulcerative colitis can lead to death.

Can ulcerative colitis be prevented?

Experts don’t know what causes ulcerative colitis. They also don’t know how to stop the disease from happening.

Living with ulcerative colitis

Symptoms of ulcerative colitis can vary from person to person. Follow your health care provider’s advice on how to treat and manage the disease.

When should I call my health care provider?

Call your health care provider right away if:

  • Your symptoms come back after they have gone away
  • Your symptoms worsen
  • You have new symptoms

Key points about ulcerative colitis

  • Ulcerative colitis is when the lining of your large intestine and your rectum become red and swollen or inflamed.
  • It is part of a group of diseases called inflammatory bowel disease (IBD).
  • It affects men and women equally and seems to run in some families (is hereditary).
  • It is a long-term, chronic disease.
  • Experts don’t know what causes it.


Next steps

Tips to help you get the most from a visit to your health care provider:
  • Before your visit, write down questions you want answered.
  • Bring someone with you to help you ask questions and remember what your provider tells you.
  • At the visit, write down the names of new medicines, treatments, or tests, and any new instructions your provider gives you.
  • If you have a follow-up appointment, write down the date, time, and purpose for that visit.
  • Know how you can contact your provider if you have questions.
Online Medical Reviewer: Berry, Judith, PhD, APRN
Online Medical Reviewer: Weisbart, Ed, M.D.
Date Last Reviewed: 10/29/2013
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